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Title   인체 위장관암 조직에서의 MDR1 유전자 발현에 관한 연구 ( MDR1 Gene Expression in Gastric and Colorectal Cancer Tissures )
Publicationinfo   1991 Jan; 023(01): 54-65.
Key_word   Gastric cancer, Colorectal cancer, Multidrug resistance (MDR)
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Abstract   Drug resistance is an obstacle to the treatment of cancer patients. Multidrug resistance (MDR) is one of the drug resistance mechanism: expression of P-glycoprotein which is an energy-dependent drug efflux pump encoded by the MDR1 gene. The objectives of this study are to assess the frequency of MDR1 gene expression in gastric cancer tissue and to find which subgroup of gastric cancer has MDR1 gene expression. Colorectal cancer, which is knawn to have high MDR expression rate, was checked for MDR expression as postive control and for any subgroup without MDR expression. MDR1 RNA level of cancer tissue was measured by slot blot analysis, using total RNAs. In gastric cancer, three (13.6%) aut of 22 gastric carcinoma specimens were MDR (+), whose pathologic types were well differentiated, mucinous and signet ring cell type. All 8 normal gastric nonnal mucosa specimens near the tumor were MDR (-). In colorectal carcinoma, ten (58.8%) out of 17 specimens were MDR (+). In gastric cancer tissue the significance of correlation between MDR expression and pathologic differentiation was borderline (p=0.05). Though there was borderline significance in correlation, the finding that MDR1 gene expression was present in well differentiated, mucinous and signet ring cell type of gastric cancer tissue suggest some possibility that pathologic differentiation might be used as a guid to select Adriamycin for gastric cancer patient.
저 자   양한광(Han Kwang Yang),박재갑(Jae Gahb Park),김진복(Jin Pok Kim),로리골드스타인(Lori Goldstein)